Cancer The Most Important Causes And Complications Of...

Breast cancer is the most prevalent cancer identified in women, and in spite of substantial developments in cancer treatment, it is still the second most important cause of cancer-related deaths. In general, up to 25% of breast cancer patients overexpress HER2 gene. Recently, the mAbs that identify antigens on cancer cells are being used for the targeted therapy of cancer. The antibodies can be used alone or as conjugates for the transport of radioisotopes, toxins, or drugs. Immunotoxins are manufactured by the connection of an antibody to a toxin produced by a plant or a bacteria. In this study, Pseudomonas endotoxin A (PE) and Shiga toxin (STX) and Fv fragments of the anti-ErbB2 mAb herceptin was used to create a single-chain variable†¦show more content†¦Overexpression of the ErbB2 gene has beenfound in many human cancers including lung, breast, ovary, and stomach malignancies(2). About 25% of breast cancer patients overexpress HER2 gene(3, 4). Amplification of HER2 gene has been directly related to the malignant alteration of cancer cells, and therefore, makes it a great target for immunotoxin therapy. This finding has led to the development and approval of the first HER2-targeted therapy(4). Altogether, it is essential to target tumor cells using considerably strong lethal agent as cancer therapeutics.. On one hand, this approach makes it possible to use more potent drugs to treat cancer on the other hand, it may decrease systematic toxicity(5). Antibody-based therapeutics are of high significance in cancer therapy and mAbs that identify antigens on cancer cells are being recruited for the targeted cancer therapy (6). In HER2-positive breast cancer patients, numerous HER2-targeted therapeutics have been effectively designed and approved for the cancer treatment. Trastuzumab (Herceptin), the first accessible HER2 targeted therapy, is a humanized murine IgG monoclonal antibody that binds to the HER2. Antitumor activity of trastuzumab has not been discovered entirely, but, it is assumed to result in antibody dependent cell mediated cytotoxicity, declined intracellular signal transduction, decreased DNA repair and anti angiogenic effects(7). Trastuzumab based treatment policy has established a landmark in theShow MoreRelatedBreast Cancer : The Second Most Common Cause Of Cancer Essay1612 Words   |  7 Pages Breast Cancer Part A:- According to Cancer council Australia, Breast cancer was the second most common cause of cancer death in women in 2012 whereas it is expected to be the 3rd most common cause of cancer death this year. In 2012, 15166 cases of new breast cancer were diagnosed whereas the estimated number of new breast cancer diagnosis in 2016 is about 16084 with 90% five year survival rate. (Cancer Australia â€Å", 2016). 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